AMP-Activated Protein Kinase Regulates E3 Ligases in Rodent Heart
نویسندگان
چکیده
منابع مشابه
AMP-activated protein kinase regulates E3 ligases in rodent heart.
RATIONALE The degradation of proteins by the ubiquitin proteasome system (UPS) is required for the maintenance of cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). AMPK activation inhibits protein synthesis and activates autophagy, but whether AMPK plays a role in regulating protein breakdown through the UPS in the heart i...
متن کاملIntegrative Physiology AMP-Activated Protein Kinase Regulates E3 Ligases in Rodent Heart
Rationale: The degradation of proteins by the ubiquitin proteasome system (UPS) is required for the maintenance of cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). AMPK activation inhibits protein synthesis and activates autophagy, but whether AMPK plays a role in regulating protein breakdown through the UPS in the heart ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2011
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.111.252742